It is roughly as accurate to say that small = short lived as it is to say that small = unsafe. I had a Nissan Sentra (first year it was out) with a 1.5 litre engine, and that little sucker carried me and my wife and daughter 200,000 before I finally traded in on a newer car. At the time I got rid of it, the engine was still strong, but the seats were worn out. I also had a '71 Pinto that lasted 104,000, and I was not in a position to replace the main seal (the only problem) when I had to get rid of it.
So you cannot convince me that, given a properly engineered and maintained car/engine, that size counts for anything.