It would depend on how fast the smart was going before hitting the pickup bed . . .
Seriously, a 3/4 ton truck would handle the weight load; I used to regularly load mine with 2200 pounds or so. It's just the width of the bed that would be bothersome. Most can handle a 4 foot wide plywood between the fender wells, but I think the smart would be too wide. . . and then there is the whole other problem of getting it in and out of there, too.

Let us know if you do - and take some photos~!