On 2-12-1922 I drove rt from Phoenix to Yuma,Az at 65mph/cruse control on regular fuel. after driving 200+ miles, when I stoped the car,code P006e check engine lite on. I would reset it and then continue. To keep it out of detonation, I would be very careful to keep engine out of boost---(almost impossible) as every time the trans would upshipt, the engine would go into boost. SO, I went 390.9 miles, low fuel lite came on at 382 miles . refueled at390.9 miles, topped off at 7.468 gallon at overflow. So, 52.3 mpg. When I topped off , i used Premium fuel after resitting P006e code. Interesting observation: As I suspect, the ecu software is very sophisticated because the engine performance was greatly reduced and my conclusion is that detonation was detected and the software de-tuned the engine to prevent detonation engine damage, how I'm but not sure but power was definitely limited---no acceleration!! Several things contribute to detonation. Some are 1) temperature, ign timing, compression ratio/boost, fuel grade. Drove the car after refueling, found power was not there, definatly powerlimited!! Drove another 30 miles home. Then this morning , tried topping off fuel again. Noticed great improvement in power----had returned to what I call normal. Also, on regular fuel, The car would slow down on upgrades because with cruse control on, there wasn't enough power to maintain constant speed.
Botton line, run regular fuel on this car--2016 453 with 90k miles,software is smart enough to automatically adjust tuning to prevent engine damage from poor grade fuel!! And then return tune---after some time to previous settings once time/ mileage or some other parameter verifies the condition has been resolved. Strictly an observed possibility. Unfortunately I don't have copy of the software to see what the code is doing. Perhaps the factory shop/service manual has a description of software functions. Next time I am taking a long trip, I can use regular fuel with some confidence the engine will be de tuned automatically. I will also repeat this experiment with ethanol free regular gas as this fuel has a much higher energy content per pound. Look at Reid vapor pressure of gasoline, Important to know about this---makes a difference in fuel mileage as fuel additive packages are changed based on seasons/ locations etc.